1989). Redness. This site needs JavaScript to work properly. In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. Diethylene glycol monobutyl ether had no effect on the offspring of rats given oral doses of up to 633 mg/kg body weight and day, or of rats treated dermally with up to 2000 mg/kg body weight and day, or of rabbits given up to 1000 mg/kg body weight and day (see The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. In pesticide products, DEGBE acts as an inert ingredient as a deactivator for formulation before the crop emerges from the soil and as a stabilizer. Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. It is under evaluation by the European Union through French research, for its safety where it is absorbed into the skin. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. Dry skin. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. A MAK value of 10 ml/m3 was established for diethylene glycol monobutyl ether. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. In diffusion cell experiments with excised human skin, a flux of 59±36.2 µg/cm2 and hour was calculated for undiluted diethylene glycol monobutyl ether acetate. If you do not receive an email within 10 minutes, your email address may not be registered, In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). 2004). What is Diethylene Glycol Monobutyl Ether? Diethylene glycol is an organic compound with the formula (HOCH2CH2)2O. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). and you may need to create a new Wiley Online Library account. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. Ingestion. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. After the application of 2000 mg/kg body weight, the males and females eliminated 12% and 13% of the radioactivity with the urine and 0.4% and 1.4% with the faeces, respectively. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. 1993). When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. Please check your email for instructions on resetting your password. Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. Damage to skin was calculated by comparing the water absorption rates of skin before and after exposure to the test compound. Diethylene glycol monobutyl ether for synthesis Synonym: Butyl carbitol, 2-(2-Butoxyethoxy) ethanol, Butyl diglycol, Diethylene glycol monobutyl ether CAS Number 112-34-5. Clipboard, Search History, and several other advanced features are temporarily unavailable. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. They react with oxoacids and carboxylic acids to … As a result of the inadequate documentation, this study cannot be included in the evaluation. Molecular Weight 162.23 . Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). DEG is a widely used solvent. Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium. Methods: Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. If released to air, a vapor pressure of 1.18X10-3 mm Hg at 25 °C indicates diethylene glycol hexyl ether will exist solely as a vapor in the atmosphere. diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether ... provide you with protective clothing if necessary in order to protect you from skin contact with the glycol ethers marked with an "S"in the table above. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. log KOW Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Rinse skin with plenty of water or shower. Traces of 2‐butoxy acetic acid were detected. In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. Metabolites of diethylene glycol monobutyl ether acetate. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Working off-campus? 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see ... Diethylene Glycol is an aliphatic diol. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). The ether being relatively unreactive. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. (2012) Diethylene glycol monobutyl ether [MAK Value Documentation, 1996] The MAK-Collection for Occupational Health and Safety, 10.1002/3527600418.mb11234e0007, (60-67) Bevan Ph.D C (2001) Monohydric Alcohols-C7 to C18, Aromatic, and Other Alcohols Patty's Toxicology , 10.1002/0471435139.tox078 There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. 2018 Oct 31;13(10):e0205458. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. INHALED There is some evidence to suggest that the material can cause respiratory irritation in some persons. “Diethylene glycol monobutyl ether” 2008). Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. ):128-34. doi: 10.1007/s00420-002-0367-8 was a metabolite or an impurity of skin before and after to! 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